The association between the serum C-peptide level and bone mineral density
Ying Li1, Hua Liu2, Yasuto Sato3
1Department of Social Medicine, School of Public Health, Zhejiang University, Zhejiang, China.
Plos One
|December 21, 2013
Summary
Serum C-peptide levels are negatively associated with bone mineral density (BMD) in US adults. Lower C-peptide may indicate higher risk for low BMD, suggesting C-peptide management is important for bone health.
Area of Science:
- Endocrinology
- Bone Metabolism
- Biochemistry
Background:
- Serum C-peptide, once thought inactive, is now recognized for its physiological roles.
- Emerging evidence highlights C-peptide's involvement in various bodily functions.
Purpose of the Study:
- To investigate the association between serum C-peptide levels and bone mineral density (BMD) in a diverse US population.
- To determine if serum C-peptide influences bone health.
Main Methods:
- Analysis of data from 6,625 US residents aged 12-85 years.
- Bone mineral density (BMD) measured using dual-energy X-ray absorptiometry.
- Stratified multiple linear regression models adjusted for various demographic and clinical factors.
Main Results:
- A significant negative association was observed between serum C-peptide levels and total BMD in both males and females.
- Serum C-peptide levels were significantly negatively associated with most regional BMD measures.
- These associations persisted even after adjusting for serum insulin levels.
Conclusions:
- Serum C-peptide levels are significantly negatively correlated with total and regional bone mineral density.
- Findings suggest serum C-peptide possesses biological activity influencing bone metabolism.
- Controlling serum C-peptide levels may be beneficial in reducing the risk of low bone mineral density.
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