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Published on: November 21, 2013
Clozapine prescribing in a Canadian outpatient population
Silvia Alessi-Severini1, Josee-Anne Le Dorze1, David Nguyen1
1Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada.
Objective:
Description of demographics of an outpatient population of clozapine users.
Methods:
Retrospective chart review study of an urban population diagnosed with schizophrenia. Assessment of therapeutic histories in relation to clinical practice guidelines.
Results:
Seventy-seven of the 467 patients were on clozapine therapy. Average patients' age was 39.4 ± 11.8 years) and 68% were males. The majority of patients (68%) had tried 3 or more antipsychotics before switching to clozapine, 21% had tried two and 11% had tried one. Median length of therapy prior to clozapine initiation was 8.9 years in males and 7.7 years in females.
Conclusion:
Until 2010, the use of clozapine was often delayed and more than 2 antipsychotic medications were tried for relatively long periods of time before patients were switched to this effective agent.
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