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Updated: May 4, 2026
A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
[Occurrence and molecular pathology of low grade gliomas]
Balázs Murnyák1, Tamás Csonka1, Almos Klekner2
1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Neuropatológiai Tanszék, Debrecen.
Background:
The WHO grade I. and II. low-grade gliomas represent nearly the 15% of all primary brain tumors. These tumours contain clinically, histologically and molecularly distinct tumor types. According to their histologic characteristic, grade II glial tumours are the diffuse astrocytoma, oligodendroglioma and oligoastrocytoma subgroups; ependymal tumors are not included in this study.
Methods:
In our publication, we analysed the histologically diagnosed glioma cases between 2007 and 2011 at our institution.
Results:
Low-grade gliomas were diagnosed in 127 cases (62 male / 65 female), and the mean ages were 39 years (+/- 20.3). More than half of the cancers were localized in the frontal lobe, and the second most frequent area was the temporal lobe. Finally, we complete our report with an overview of major molecular pathways in low-grade gliomas.
