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Related Experiment Video

Updated: May 4, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
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Severe adenomyosis and CA125.

S S Sheth1, S S Ray

  • 1Breach Candy, Sir Hurkisondas and Saifee Hospitals and Sheth Gynecological Nursing Home.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|December 24, 2013
PubMed
Summary

Severe adenomyosis can cause elevated CA125 levels, correlating with uterine size. However, enlarged uteri from fibroids do not significantly raise CA125, suggesting benign causes for elevated levels.

Area of Science:

  • Gynecology
  • Oncology

Background:

  • Adenomyosis is a condition causing uterine enlargement.
  • CA125 is a tumor marker often monitored in gynecological conditions.

Purpose of the Study:

  • To investigate the relationship between uterine size due to adenomyosis and CA125 levels.
  • To differentiate CA125 levels in adenomyosis versus uterine fibroids.

Main Methods:

  • Studied 50 women with uterine enlargement due to severe adenomyosis and elevated CA125.
  • Compared CA125 levels in adenomyosis with those in uterine fibroids of similar size.

Main Results:

  • Uterine enlargement (>12 weeks size or 240 cm³ volume) from severe adenomyosis correlated with increased CA125 levels.
  • Significantly elevated CA125 levels were observed in some adenomyosis cases.

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  • Uterine fibroids did not cause a significant rise in CA125 levels.

    • Conclusions:

    • Elevated CA125 in the context of uterine enlargement may indicate adenomyosis rather than malignancy.
    • Benign causes like adenomyosis can lead to high CA125, reducing anxiety when clinical findings are benign.