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Updated: May 4, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Virus-induced signaling influences endosome trafficking, virus entry, and replication
David J Marchant1, Leanne Bilawchuk1, Gordon Nish1
1Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Abstract:
Viruses are obligate intracellular pathogens that interact with host cell machinery for enabling entry, replication, and spread. This chapter describes methods for studying the interaction of viruses with host cell signaling pathways and surface receptors during cellular infection, with an emphasis on protein kinases. We also describe how use of immunofluorescence confocal microscopy for imaging virus-host interactions provides a powerful approach for obtaining structural correlations that extend results of immunological and biochemical assays.
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