Genetic circuitry modulating notch signals through endosomal trafficking
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Updated: May 4, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
Published on: March 22, 2018
Kazuya Hori1, Anindya Sen1, Spyros Artavanis-Tsakonas1
1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Genetic modifier screens offer a powerful, indeed a uniquely powerful tool for the analysis and identification of elements capable of modulating specific cellular functions in development. Here, we describe the methodology that allowed us to explore the genetic circuitry that affects a Notch mutant phenotype caused by the abnormal endosomal trafficking of the Notch receptor. Endosomal trafficking events are increasingly appreciated to play a major role in controlling Notch signaling in development.
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