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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Related Experiment Video

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development.

Leslie Ratié, Michelle Ware, Frédérique Barloy-Hubler

  • 1Institut de Génétique et Développement de Rennes, CNRS UMR6290, Université de Rennes 1, IFR140 GFAS, Faculté de Médecine, Rennes, France. valerie.dupe@univ-rennes1.fr.

Neural Development
|December 24, 2013
PubMed
Summary

Notch signaling regulates neuron generation in the developing hypothalamus via lateral inhibition. This study identifies Tagln3 and Chga as novel downstream targets of this crucial developmental pathway.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neuronal diversity is essential for central nervous system function.
  • Notch signaling is a known regulator of neurogenesis.
  • The role of Notch in hypothalamus development is largely unknown.

Purpose of the Study:

  • Investigate Notch signaling's role in early hypothalamus formation.
  • Identify downstream effectors of Notch in the developing hypothalamus.

Main Methods:

  • Transiently blocked Notch activity in chick embryos.
  • Utilized global gene expression analysis.
  • Identified novel gene targets.

Main Results:

  • Notch signaling modulates hypothalamic neuron generation through lateral inhibition.
  • Identified Tagln3 and Chga as novel Notch signaling targets.
  • These targets are expressed in hypothalamic neuronal nuclei.

Conclusions:

  • Inhibition of Notch signaling enhances new marker expression in the hypothalamus.
  • Tagln3 and Chga are important new targets of the Notch/proneural network.
  • Provides insights into early hypothalamic neurogenesis.