Related Experiment Video

Updated: May 4, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K

[Antibiotherapy of severe ENT infections in children: complicated sinusitis]

H Haas1, M Lorrot2, V Hentgen3

  • 1Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie; Service d'urgences pédiatriques - Infectiologie, hôpitaux pédiatriques CHU Lenval, 57 avenue de la Californie, 06200 Nice, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|December 24, 2013
PubMed

Insights

Orbital cellulitis and abscesses, frequent sinusitis complications, require tailored antibiotic regimens. Treatment varies by Chandler classification, from oral amoxicillin-clavulanate for preseptal cellulitis to high-dose IV antibiotics for severe cases.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Context:

  • Bacterial sinusitis frequently leads to intraorbital or extraorbital cellulitis and abscesses.
  • Predominant pathogens include Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, and anaerobic bacteria.
  • Haemophilus influenzae is a less common cause, particularly since the advent of type b vaccination.

Purpose:

  • To outline evidence-based antibiotic treatment strategies for bacterial complications of acute sinusitis.
  • To propose probabilistic antibiotic regimens based on bacterial sensitivity, pharmacokinetic/pharmacodynamic (PK/PD) parameters, and Chandler's classification of orbital infections.

Summary:

  • Chandler classification guides treatment: Class 1 (preseptal cellulitis) may be treated with oral amoxicillin-clavulanate or intramuscular ceftriaxone.
  • Classes 2-5 (orbital cellulitis/abscess) necessitate high-dose intravenous antibiotics, such as amoxicillin-clavulanate, or combination therapy with ceftriaxone/cefotaxime and anti-anaerobic agents like metronidazole or clindamycin.

Impact:

  • Provides clinicians with a structured approach to managing serious bacterial complications of sinusitis.
  • Aims to optimize antibiotic selection and dosing for improved patient outcomes and reduced antimicrobial resistance.

More Related Videos

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

1.4K
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes03:53

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

1.3K

Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
679
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
842
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
3.9K
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
21
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
6.6K
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
219