Phenindione interference in enzymatic creatinine assay - A case report
Phenindione interferes with enzymatic creatinine tests, leading to inaccurate results. This drug can cause misclassification of chronic kidney disease (CKD) severity due to falsely low creatinine levels.
Area of Science:
- Clinical Chemistry
- Pharmacology
- Nephrology
Background:
- Enzymatic creatinine assays offer superior specificity compared to traditional Jaffe methods.
- Accurate creatinine measurement is crucial for diagnosing and managing chronic kidney disease (CKD).
Observation:
- A case report identified phenindione interference with an enzymatic creatinine assay.
- This interference led to significant misclassification of a patient's CKD status.
Findings:
- Analysis of 36 patients treated with phenindione revealed significant negative interference with the Roche enzymatic creatinine assay.
- Phenindione causes falsely decreased creatinine levels, impacting diagnostic accuracy.
Implications:
- Clinicians must be aware of potential phenindione interference when interpreting enzymatic creatinine results.
- Consider alternative assays or monitoring strategies for patients on phenindione therapy to ensure accurate CKD assessment.
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