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Updated: May 4, 2026

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

Tissue-engineered kidney disease models.

Teresa M Desrochers¹, Erica Palma¹, David L Kaplan¹

¹Department of Biomedical Engineering, Tufts University, Medford, MA, USA.

Advanced Drug Delivery Reviews

|December 24, 2013

Summary

Tissue engineered kidney models offer advanced solutions for studying renal diseases, overcoming limitations of traditional methods. These innovative models aid in developing future treatments and preclinical drug testing for kidney failure.

Keywords:

3D tissues Acute kidney injury Chronic kidney disease Drug-induced nephrotoxicity Glomerulus Microfluidics Polycystic kidney disease Renal Renal cell carcinoma Renal fibrosis

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Area of Science:

Biomedical Engineering
Nephrology
Regenerative Medicine

Background:

Renal diseases are a significant global health burden, frequently leading to end-stage renal failure requiring dialysis or transplantation.
Traditional research methods like patient observation, animal models, and 2D cell cultures have inherent limitations in fully recapitulating kidney disease complexity.
There is a critical need for advanced models that can better mimic human kidney physiology and pathology.

Purpose of the Study:

To review recent advancements in tissue-engineered kidney disease models.
To highlight how these models address the shortcomings of conventional research approaches.
To explore the potential of these models in guiding future therapeutic strategies and preclinical drug development for renal conditions.

Main Methods:

Discussion of cells and biomaterials used in constructing tissue-engineered kidney models.
Detailed examination of specific engineered models, including those for polycystic kidney disease, drug-induced nephrotoxicity, and glomerular structures.
Synthesis of current literature on the development and application of these advanced models.

Main Results:

Tissue-engineered models provide a more physiologically relevant platform for studying renal diseases compared to traditional methods.
These models allow for detailed investigation of specific kidney pathologies like polycystic kidney disease and nephrotoxicity.
The review details the components and construction of various engineered kidney models, including glomerular and disease-specific constructs.

Conclusions:

Tissue-engineered kidney models represent a significant leap forward in understanding and treating renal diseases.
These models have the potential to revolutionize preclinical drug development and personalize treatment strategies for kidney patients.
Further development and application of these models are expected to accelerate progress in nephrology research and clinical practice.