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The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies

Zachary S Scheiner1, Sohel Talib, Ellen G Feigal

  • 1From the California Institute for Regenerative Medicine, San Francisco, California 94107.

The Journal of Biological Chemistry
|December 24, 2013
PubMed

Induced pluripotent stem cell (iPSC) technology offers the promise of immune-matched cell therapies for a wide range of diseases and injuries. It is generally assumed that cells derived from autologous iPSCs will be immune-privileged. However, there are reasons to question this assumption, including recent studies that have tested iPSC immunogenicity in various ways with conflicting results. Understanding the risk of an immune response and developing strategies to minimize it will be important steps before clinical testing. Here, we review the evidence for autologous iPSC immunogenicity, its potential causes, and approaches for assessment and mitigation.

Keywords:
Cell TherapyCellular Immune ResponseHumoral ResponseInduced Pluripotent Stem CellsInnate ImmunityiPSC

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