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Updated: Jan 4, 2026

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

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Oxidative stress in twins.

Ingrid Brucknerova1, Eduard Ujhazy2, Michal Dubovicky2

  • 11st Department of Paediatrics, Medical School, Comenius University, Bratislava, Slovakia. osmium@centrum.sk.

Neuro Endocrinology Letters
|December 24, 2013
PubMed
Summary
This summary is machine-generated.

This study examined antioxidant markers in premature identical twins, finding differences between twins and over time. These findings highlight the importance of the total antioxidant system (TAS) for newborns facing oxidative stress.

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Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Perinatal Research

Background:

  • Premature birth poses significant risks to newborns, including oxidative stress.
  • Identical twins may experience different physiological conditions due to birth order and delivery dynamics.
  • Assessing antioxidant status is crucial for understanding neonatal adaptation and vulnerability.

Purpose of the Study:

  • To evaluate the total antioxidant system (TAS) and malondialdehyde (MDA) levels in premature identical twins.
  • To compare TAS and MDA values between the first-born (A) and second-born (B) twin.
  • To analyze changes in these markers on the 1st and 5th day of life.

Main Methods:

  • Biochemical analysis of blood samples from premature identical twins.
  • Measurement of total antioxidant system (TAS) activity.
  • Quantification of malondialdehyde (MDA) as a marker of lipid peroxidation.

Main Results:

  • Significant differences in TAS and MDA values were observed between twin A and twin B.
  • Distinct variations in TAS and MDA levels were recorded between the 1st and 5th day of life.
  • The study confirmed disparities in oxidative stress markers between co-twins.

Conclusions:

  • TAS values reflect the newborn's capacity to combat oxidative stress during delivery.
  • In twin pregnancies, TAS is critical for determining the severity of birth asphyxia consequences.
  • MDA levels serve as an indicator of ongoing lipoperoxidation in newborns.