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Updated: May 4, 2026
Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types
Florian T Merkle1, Luis C Fuentealba2, Timothy A Sanders3
11] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Eli and Edythe Broad Center of Regeneration, Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA. [3] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA. [4] Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA. [5] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA. [6].
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Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb. The full extent of diversity among adult NSCs and their progeny is not known. Here, we report the generation of at least four previously unknown olfactory bulb interneuron subtypes that are produced in finely patterned progenitor domains in the anterior ventral V-SVZ of both the neonatal and adult mouse brain. Progenitors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that correlate with the expression domains of the Nkx6.2 and Zic family of transcription factors. This work reveals an unexpected degree of complexity in the specification and patterning of NSCs in the postnatal mouse brain.
