Related Experiment Video

Updated: May 4, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

575

Role of microRNAs in stroke and poststroke depression

Han Yan1, Min Fang1, Xue-Yuan Liu1

  • 1Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle Yanchang Road No. 301, Zhabei District, Shanghai 200072, China.

Thescientificworldjournal
|December 24, 2013
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are vital for nervous system development. This review explores their role in cerebral ischemia and post-stroke depression, aiding clinical diagnosis and prognosis.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • MicroRNAs (miRNAs) are noncoding RNAs regulating gene expression in eukaryotes.
  • They are implicated in crucial physiological and pathological processes, including disease progression.
  • miRNAs play a significant role in nervous system development.

Purpose of the Study:

  • To review the role of miRNAs in cerebral ischemia.
  • To examine the involvement of miRNAs in post-stroke depression (PSD).
  • To assess the potential of miRNAs for diagnosing and predicting outcomes of cerebral ischemia and PSD.

Main Methods:

  • Literature review of studies on miRNA function in cerebral ischemia and PSD.
  • Analysis of research on miRNA involvement in neurological disease pathogenesis.
  • Synthesis of findings regarding miRNA biomarkers in clinical practice.

Main Results:

  • Certain miRNAs are critical in the development of ischemic cerebrovascular diseases like stroke.
  • miRNAs are also involved in the occurrence and progression of post-stroke depression.
  • Emerging evidence highlights miRNAs' potential as diagnostic and prognostic indicators.

Conclusions:

  • miRNAs are key regulators in the context of cerebral ischemia and PSD.
  • Understanding miRNA mechanisms offers insights into disease pathology.
  • miRNAs may serve as valuable biomarkers for clinical applications in stroke and related conditions.

More Related Videos

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

9.4K
Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint06:15

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

187

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K