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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Related Experiment Video

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Renal cell carcinoma: Evolving and emerging subtypes.

Suzanne M Crumley1, Mukul Divatia1, Luan Truong1

  • 1Suzanne M Crumley, Mukul Divatia, Luan Truong, Steven Shen, Alberto G Ayala, Jae Y Ro, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Cornell Medical College of Cornell University, Houston, TX 77030, United States.

World Journal of Clinical Cases
|December 24, 2013
PubMed
Summary

This review summarizes recent advances in renal cell carcinoma (RCC) understanding. It details newly defined renal tumors, crucial for accurate diagnosis, treatment, and prognosis of kidney cancer.

Keywords:
11) translocationAcquired cystic kidney diseaseCandidate entitiesCarcinoma associated with neuroblastoma recently described entitiesClear cell papillary renal cell carcinomaHereditary leiomyomatosisMucinous tubular and spindle cellMultilocular cystic clear cellRenal cell carcinomaRenal cell carcinoma with t(6SubtypesXp11 translocation

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Knowledge of renal cell carcinoma (RCC) is rapidly expanding.
  • New renal tumors are being defined, altering understanding of their biology and clinical features.

Purpose of the Study:

  • To provide a targeted summary of new developments in renal cell carcinoma.
  • To highlight evolving concepts and newly described entities in RCC.

Main Methods:

  • Review of recent literature on renal cell carcinoma.
  • Synthesis of information on newly defined and candidate RCC entities.

Main Results:

  • Discussion of Xp11 translocation carcinoma, mucinous tubular and spindle cell carcinoma, multilocular cystic clear cell RCC, and neuroblastoma-associated carcinoma.
  • Description of tubulocystic carcinoma, thyroid-like follicular carcinoma, acquired cystic disease-associated RCC, and clear cell papillary RCC.
  • Review of candidate entities: RCC with t(6;11) translocation, hybrid oncocytoma/chromophobe RCC, hereditary leiomyomatosis and RCC syndrome, and renal angiomyoadenomatous tumor.

Conclusions:

  • Understanding new RCC entities is critical for diagnosis, treatment, and prognosis.
  • This review offers a concise overview of recent advancements in RCC.