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Published on: December 6, 2016
[Changes of serum aminotransferase in children with obstructive sleep apnea hypopnea syndrome]
1Department of Pediatrics, the Affiliated Jinxiang Hospital of Jining Medical College, Jining, 272200, China.
Insights
Obstructive sleep apnea hypopnea syndrome (OSAHS) may independently increase the risk of liver injury in children, even after accounting for obesity. Obese children with OSAHS show higher liver enzyme levels, indicating potential liver damage.
Area of Science:
- Pediatric Gastroenterology
- Sleep Medicine
- Hepatology
Context:
- Non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnea hypopnea syndrome (OSAHS) are prevalent conditions often linked to childhood obesity.
- The independent contribution of OSAHS to liver injury, separate from obesity, remains unclear.
Purpose:
- To investigate whether obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for liver injury in children.
- To assess the association between OSAHS and elevated liver enzymes, considering obesity as a confounding factor.
Summary:
- A study involving 130 children with OSAHS and 77 with primary snoring (PS) measured polysomnography, BMI, liver function, lipids, glucose, and insulin.
- Children with OSAHS exhibited significantly higher rates of elevated serum aminotransferase levels compared to controls (P < 0.05).
- Obese children also showed elevated aminotransferase levels more frequently than non-obese children (P < 0.05), with 93.3% of obese children with elevated enzymes having OSAHS.
Impact:
- Findings suggest OSAHS may be an independent risk factor for liver injury in children.
- Increased liver enzyme levels are common in obese children with snoring, particularly those diagnosed with OSAHS.
- This highlights the importance of screening for OSAHS in obese children with potential liver issues.
Objective:
Obstructive sleep apnea hypopnea syndrome (OSAHS) and non-alcoholic fatty liver disease (NAFLD) are both strongly associated with obesity. Whether OSAHS is an independent risk factor for liver injury or not is uncertain. To assess the hypothesis that OSAHS is associated with liver injury independent of obesity.
Method:
One hundred and thirty children with OSAHS and 77 children with primary snoring(PS) were enrolled. Polysomnography was performed. Body mass index (BMI), liver function tests, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured.
Result:
Seventeen children of OSAHS had elevated serum aminotransferase levels,while only 2 children of non-OSAHS had elevated serum aminotransferase in healthy control group (chi2 = 5.18, P < 0.05; OR = 5.64 CI 1.27-24.97). Fifteen children of obese had elevated serum aminotransferase levels, while only 4 children had elevated serum aminotransferase in non-obese group (chi2 = 4.58, P < 0.05; (OR = 1.97 CI 1.06-3.67). Seventy cases of obese children, 15 cases of elevated aminotransferase levels (21.4%), namely fatty liver patients, of these children, 14 had OSAHS (93.3%). In contrast, OSAHS was present in only 67.3% of obese children without elevated aminotransferase.
Conclusion:
OSAHS may be a risk factor for liver injury independent of obesity; Increased liver enzyme levels are frequently found in obese snoring children, particularly among those with OSAHS.
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