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Updated: May 4, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
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Tissue composition changes and secondary lymphedema.

E S Dylke1, L C Ward, J D Meerkin

  • 11 Faculty of Health Sciences, University of Sydney , Sydney, Australia .

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|December 25, 2013
PubMed
Summary
This summary is machine-generated.

Limb tissue composition changes in lymphedema are influenced by arm dominance and severity. These findings impact diagnosis, monitoring, and treatment of secondary lymphedema.

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Area of Science:

  • Medical imaging
  • Physiology
  • Clinical research

Background:

  • Lymphedema significantly alters limb tissue composition.
  • Understanding these changes is crucial for effective management.
  • Dual-energy X-ray absorptiometry (DXA) offers a method to assess tissue composition.

Purpose of the Study:

  • To investigate how arm dominance and lymphedema severity affect tissue composition.
  • To correlate DXA-derived tissue volumes with clinical outcomes from perometry and bioimpedance spectroscopy.

Main Methods:

  • Dual-energy X-ray absorptiometry (DXA) was used to measure upper limb tissue composition.
  • Perometry and bioimpedance spectroscopy (BIS) were employed for clinical outcome assessment.
  • Study included women with secondary lymphedema and a control group.

Main Results:

  • Arm dominance significantly impacted inter-limb tissue volume differences and interacted with lymphedema severity.
  • In lymphedema patients, affected arm fat increase was not linked to overall body adiposity when the dominant arm was affected.
  • DXA findings showed moderate to high correlation with perometry and BIS measurements.

Conclusions:

  • Limb composition changes in lymphedema are influenced by arm dominance and disease severity.
  • These compositional shifts may affect the diagnosis, monitoring, and treatment strategies for secondary lymphedema.