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Pertactin-negative variants of Bordetella pertussis in New York State: a retrospective analysis, 2004-2013

Tammy Quinlan1, Kimberlee A Musser1, Salvatore A Currenti2

  • 1Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, NY 12201-2002, United States.

Molecular and Cellular Probes
|December 25, 2013
PubMed

Insights

Pertactin-negative Bordetella pertussis variants emerged in the US, prompting investigation into their link with acellular pertussis vaccines and rising pertussis cases. Sequence analysis identified specific gene mutations in these variants.

Area of Science:

  • Microbiology
  • Vaccinology
  • Genetics

Background:

  • Recent increases in pertussis (whooping cough) cases have been observed in the United States.
  • The emergence of pertactin-negative variants of Bordetella pertussis has been reported.
  • Pertactin is a key component of current acellular pertussis vaccines.

Purpose of the Study:

  • To identify the specific genetic mutations responsible for pertactin-negative Bordetella pertussis variants.
  • To investigate the association between these variants and the vaccination status of affected individuals.

Main Methods:

  • Utilized a sequence-based method for genetic analysis of Bordetella pertussis isolates.
  • Collected and analyzed data on the vaccination status of patients with pertussis.

Main Results:

  • Identified specific mutations within the pertactin gene correlating with the emergence of pertactin-negative variants.
  • Assessed the vaccination history of individuals infected with these variants.

Conclusions:

  • The study provides genetic insights into the evolution of Bordetella pertussis.
  • Further research is needed to understand the implications of these variants for vaccine efficacy and public health strategies against pertussis.
Keywords:
Acellular vaccineBordetella pertussisPertactin-negative variants

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