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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
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Acute and chronic respiratory failure
Sabin Oana1, Jayanta Mukherji1
1Department of Anesthesiology, Loyola University Medical Center, Maywood, IL, USA.
Handbook of Clinical Neurology
|December 25, 2013
Summary
Neuromuscular diseases (NMDs) can cause respiratory failure (RF), requiring treatment that progresses from minimal support to mechanical ventilation (MV). Comprehensive care plans must align with patient preferences and current evidence-based guidelines.
Area of Science:
- Neurology
- Pulmonology
- Critical Care Medicine
Background:
- Respiratory failure (RF) is a significant complication of numerous neuromuscular diseases (NMDs).
- The clinical presentation of RF in NMDs varies widely, ranging from subtle to overt symptoms.
- Understanding the pathophysiology, diagnosis, and treatment of both NMDs and RF is crucial for managing these patients.
Purpose of the Study:
- To outline the principles of managing respiratory failure in patients with neuromuscular diseases.
- To emphasize the importance of evidence-based recommendations in diagnosis and treatment.
- To highlight the need for personalized treatment plans that consider disease progression and patient autonomy.
Main Methods:
- Review of current evidence-based recommendations for managing RF in NMDs.
- Discussion of the pathophysiological principles underlying RF in NMDs.
- Exploration of diagnostic approaches and treatment strategies, including respiratory support.
Main Results:
- Treatment strategies for RF in NMDs are tailored to disease progression.
- Interventions range from non-invasive respiratory support to mechanical ventilation (MV).
- A multidisciplinary approach is essential for comprehensive patient care.
Conclusions:
- Effective management of RF in NMDs requires adherence to the latest evidence-based guidelines.
- Treatment plans must be individualized, considering the natural progression of the disease.
- Incorporating patient wishes into the comprehensive care plan is paramount for optimal outcomes.
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