Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
Lineage Commitment01:21

Lineage Commitment

3.4K
Commitment is the  process whereby stem cells:
3.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.7K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.7K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Asundexian for Secondary Stroke Prevention.

The New England journal of medicine·2026
Same author

Impact of anaemia severity on functional outcome in patients with cerebral venous thrombosis: a DOAC-CVT substudy.

European stroke journal·2026
Same author

Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention.

European stroke journal·2026
Same author

Potential and limitations of computed tomography images as predictors of the outcome of ischemic stroke events: a review.

Frontiers in stroke·2026
Same author

Quality of life after decompressive surgery for severe cerebral venous thrombosis.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

Seizures after decompressive surgery for cerebral venous thrombosis.

Journal of neurology·2025

Related Experiment Video

Updated: May 4, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.0K

Chronic myeloproliferative diseases.

João Forjaz de Lacerda1, Sofia N Oliveira2, José M Ferro3

  • 1Department of Hematology and Bone Marrow Transplantation, Hospital de Santa Maria, Lisbon, Portugal.

Handbook of Clinical Neurology
|December 25, 2013
PubMed
Summary
This summary is machine-generated.

Chronic myeloproliferative disorders like essential thrombocythemia (ET) and polycythemia vera (PV) often cause neurological issues such as headaches, dizziness, and thrombosis. Primary myelofibrosis (PMF) rarely presents with neurological complications, mainly spinal cord compression.

Keywords:
Myeloproliferative disordermyelofibrosispolycythemiathombocythemiathrombosis

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

11.3K

Related Experiment Videos

Last Updated: May 4, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.0K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
08:12

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

Published on: December 22, 2016

11.3K

Area of Science:

  • Hematology
  • Neurology
  • Oncology

Background:

  • Chronic myeloproliferative disorders (MPNs) are characterized by the overproduction of myeloid cells.
  • Key MPNs include essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF).
  • Neurological manifestations can significantly impact patient quality of life in MPNs.

Purpose of the Study:

  • To review the neurological complications associated with ET, PV, and PMF.
  • To highlight the differences in neurological involvement across these MPN subtypes.
  • To inform clinicians about potential neurologic presentations in MPN patients.

Main Methods:

  • Literature review of neurological manifestations in MPNs.
  • Analysis of clinical data regarding neurologic symptoms in ET, PV, and PMF.
  • Synthesis of information on thrombosis, hemorrhage, and other neurologic events.

Main Results:

  • ET and PV commonly present with headaches, dizziness, and both venous and arterial thrombosis.
  • Intracranial hemorrhages are also observed in ET and PV.
  • Neurologic complications in PMF are infrequent, primarily involving spinal cord compression due to extramedullary hematopoiesis.

Conclusions:

  • Neurological symptoms are significant in ET and PV, often related to vascular complications.
  • PMF has a distinct pattern of rare neurological involvement, predominantly spinal.
  • Awareness of these diverse neurological manifestations is crucial for comprehensive MPN management.