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Measles, mumps, rubella, and human parvovirus B19 infections and neurologic disease

James F Bale1

  • 1Departments of Pediatrics and Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Handbook of Clinical Neurology
|December 25, 2013
PubMed

Insights

Measles, mumps, rubella, and parvovirus B19 can cause severe neurologic disease, particularly in children. Some viruses also pose risks for congenital infections and rare, fatal slow viral infections.

Area of Science:

  • Virology
  • Neurology
  • Pediatrics

Background:

  • Measles, mumps, rubella, and parvovirus B19 viruses can cause systemic illness.
  • These viruses pose risks for severe neurologic complications, especially in young children.
  • Vertical transmission and congenital infections are potential outcomes for rubella and parvovirus B19.

Purpose of the Study:

  • To review the neurologic manifestations of measles, mumps, rubella, and parvovirus B19 infections.
  • To highlight the risks of congenital infections and slow viral infections associated with these viruses.

Main Methods:

  • Literature review of viral infections and their neurologic sequelae.
  • Analysis of case studies and epidemiological data related to measles, mumps, rubella, and parvovirus B19.

Main Results:

  • Measles, mumps, rubella, and parvovirus B19 can lead to severe, life-threatening neurologic diseases.
  • Congenital rubella syndrome and congenital parvovirus B19 infection can result from maternal transmission.
  • Measles and rubella viruses are associated with fatal slow viral infections years after initial exposure.

Conclusions:

  • These common viruses represent significant threats for neurologic complications, including congenital and slow-acting infections.
  • Awareness and understanding of these viral risks are crucial for pediatric and public health.
  • Further research into prevention and treatment of these severe outcomes is warranted.
Keywords:
Measlescongenital rubella syndromehuman parvovirusmumpsrubellasubacute sclerosing panencephalitis

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