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Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs
Erik de Blois1, Ho Sze Chan1, Rory de Zanger1
1Erasmus MC Rotterdam, Department of Nuclear Medicine, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
Abstract:
For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, (111)In- and (177)Lu-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling.
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