Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

1.8K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.8K
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

259
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
259
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.6K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.6K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

1.0K
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Pharmacy Profession's Public Relations Problem: Visibility, Value, and Voice.

Journal of the American College of Clinical Pharmacy : JACCP·2026
Same author

Consensus Recommendations for Clinical Pharmacist Integration into the Acute Stroke Care Team: Endorsed by the American College of Clinical Pharmacy, Neurocritical Care Society, Society for Academic Emergency Medicine, and Society of Critical Care Medicine, and affirmed by the American Academy of Neurology.

Journal of the American College of Clinical Pharmacy : JACCP·2026
Same author

A multi-center retrospective cohort study of SUGAmmadex for neuromuscular blockade reversal in the emergency department: SUGARED study - on behalf of EMPHARM-NET Investigators.

The American journal of emergency medicine·2026
Same author

In reply.

Annals of emergency medicine·2026
Same author

Traumatic hemothorax activates complement, stimulates proinflammatory cytokine release, and primes neutrophils for local inflammatory reactive oxygen species production.

The journal of trauma and acute care surgery·2026
Same author

Closing the gaps in hyperacute stroke care: Pharmacologic and systems-level considerations.

The American journal of emergency medicine·2026

Related Experiment Video

Updated: May 4, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

1.7K

Racial differences in vasopressor requirements for septic shock.

Zachary M Bauman1, Keith F Killu, Megan A Rech

  • 1*Department of Surgical Critical Care, Henry Ford Hospital, Detroit, Michigan; †Department of Pharmacy Services, Loyola University, Chicago, Illinois; and ‡Department of Pharmacy Services, Providence Hospital, Mobile, Alabama.

Shock (Augusta, Ga.)
|December 25, 2013
PubMed
Summary

African American patients with septic shock required higher doses and longer duration of norepinephrine administration compared to white patients. This finding highlights potential racial disparities in septic shock management.

More Related Videos

Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

55.2K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

2.2K

Related Experiment Videos

Last Updated: May 4, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

1.7K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

55.2K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

2.2K

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Health Disparities

Background:

  • Septic shock management involves vasopressor use to maintain hemodynamic stability.
  • Understanding racial differences in treatment response is crucial for equitable care.

Purpose of the Study:

  • To compare vasopressor requirements between African American and white patients diagnosed with septic shock.
  • To identify potential racial disparities in the dosage and duration of vasopressor therapy.

Main Methods:

  • Retrospective cohort review of 159 septic shock patients over two years.
  • Analysis of total, mean, and duration of vasopressor dosing between racial groups.
  • Inclusion of comorbidities, antihypertensive use, and fluid administration in the analysis.

Main Results:

  • African Americans had higher rates of end-stage renal disease and hypertension.
  • Norepinephrine (NE) was the most common vasopressor, with African Americans receiving higher total and mean doses.
  • African Americans required a longer duration of NE administration compared to white patients (38.38 vs. 29.09 hours).

Conclusions:

  • African American patients with septic shock received higher doses and longer durations of norepinephrine.
  • These findings suggest a potential racial disparity in the management of septic shock regarding vasopressor therapy.