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Unilateral perseveration.

Lealani Mae Y Acosta1, Ira J Goodman, Kenneth M Heilman

  • 1*Department of Neurology, Vanderbilt University, Nashville, TN †The Compass Clinic, Orlando, FL ‡Department of Neurology, University of Central Florida College of Medicine, Orlando, FL §Department of Neurology, University of Florida College of Medicine, Gainesville, FL ∥The Malcom Randall Veterans Affairs Medical Center, Gainesville, FL.

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Summary
This summary is machine-generated.

This study details a progressive supranuclear palsy (PSP) patient with unique unilateral motor perseveration, specifically affecting the right hand. This finding suggests unilateral motor perseveration may indicate PSP or corticobasal syndrome.

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Neuropsychology

Background:

  • The brain's action-intentional system governs action initiation, persistence, and termination.
  • Motor perseveration, a failure to cease actions, typically stems from executive frontal-subcortical network dysfunction.
  • Unilateral motor perseveration is an uncommon presentation.

Observation:

  • A 68-year-old male patient with progressive supranuclear palsy (PSP) presented with continuous right-hand motor perseveration.
  • The patient exhibited impaired walking, vertical gaze, and word repetition, consistent with PSP.
  • Motor tasks revealed persistent perseveration in the right hand but not the left.

Findings:

  • Unilateral motor perseveration can be a clinical sign associated with PSP or corticobasal syndrome.
  • The case suggests that callosal degeneration in PSP or corticobasal syndrome may lead to unilateral perseveration.
  • This may result from callosal disconnection of the right frontal lobe from contralateral motor and speech areas.

Implications:

  • Future research should investigate asymmetric hand perseveration in PSP and corticobasal syndrome.
  • Determining the precise mechanism of unilateral motor perseveration is crucial for understanding these neurological disorders.
  • This case highlights the importance of assessing unilateral motor deficits in diagnosing and understanding frontotemporal brain network disorders.