Association between septal deviation and sinonasal papilloma

Area of Science:

• Otolaryngology
• Pathology
• Medical Imaging

Background:

• Sinonasal papilloma is a benign epithelial tumor of the sinonasal tract, accounting for 0.5-4% of nasal tumors.
• Human papillomavirus (HPV) is a suspected risk factor, but other etiological factors remain unclear.
• Anatomical variations, like deviated nasal septum, may influence sinonasal papilloma pathogenesis.

Purpose of the Study:

• To investigate the association between deviated nasal septum and the development of sinonasal papilloma.
• To explore the role of nasal cavity anatomy in the pathogenesis of sinonasal papilloma.

Main Methods:

• Retrospective analysis of preoperative CT or MRI findings in 83 patients with sinonasal papilloma.
• Evaluation of the correlation between papilloma location and the direction of septal deviation.
• Statistical analysis to determine the significance of septal deviation in papilloma development.

Main Results:

• A significant correlation was found between the side of papilloma and the direction of septal deviation.
• The concave side of septal deviation was significantly associated with sinonasal papilloma development (p = 0.040).
• Papilloma occurred on the intact side in 61.4% and the affected side in 21.7% of patients.

Conclusions:

• Deviated nasal septum, particularly on the concave side, is associated with sinonasal papilloma development.
• High incidence on the concave side may result from traumatic airflow effects and increased exposure to viruses/pollutants.
• Findings support the role of HPV and toxic chemicals in sinonasal papilloma occurrence.