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The myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030

Tobias A M Gulder1, Snežana Neff2, Traugott Schüz2

  • 1Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straβe 1, 53121 Bonn, Germany.

Beilstein Journal of Organic Chemistry
|December 25, 2013
PubMed

Keywords:
Stigmatella aurantiacaantifungal activitymyxobacterianatural productsstructure elucidation

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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