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Updated: May 4, 2026
Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
Published on: August 29, 2016
The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells
Nicolas Molnarfi1, Mahdia Benkhoucha1, Catherine Juillard2
1Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva and Faculty of Medicine, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland.
Abstract:
Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS.
