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Isolation and structure elucidation of pentahydroxyscirpene, a trichothecene Fusarium mycotoxin
Philipp Fruhmann1, Hannes Mikula, Gerlinde Wiesenberger
1Institute of Applied Synthetic Chemistry, Vienna University of Technology (VUT) , Getreidemarkt 9/163, A-1060 Vienna, Austria.
Abstract:
Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes.
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