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Related Concept Videos

Properties of Enantiomers and Optical Activity02:24

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It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
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Interchangeability of rotational elastographic instruments and reagents.

Maya Aleshnick1, Thomas Orfeo, Kathleen Brummel-Ziedins

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|December 26, 2013
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Summary

Viscoelastic measurements using TEG and ROTEM instruments show good interchangeability for hemostasis assessment, despite minor parameter differences with specific reagents. Standardization is improving for blood clot analysis.

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Area of Science:

  • Hemostasis and Thrombosis Research
  • Clinical Diagnostics
  • Biomedical Engineering

Background:

  • Viscoelastic measurements rapidly assess blood clot formation and degradation in clinical and research settings.
  • Two main instruments, TEG and ROTEM, are used with proprietary reagents, lacking standardization for result comparison.
  • This study addresses the need for standardization through a crossover analysis of TEG and ROTEM instruments.

Purpose of the Study:

  • To perform a crossover analysis between TEG and ROTEM instruments using proprietary reagents.
  • To evaluate the interchangeability of TEG and ROTEM for hemostatic measurements.
  • To identify parameters and reagents that show disparities between the two instruments.

Main Methods:

  • A crossover analysis was conducted using TEG and ROTEM instruments.
  • Three reagent sets were tested: in-tem/ex-tem, kaolin/RapidTEG, and a recombinant tissue factor-phospholipid reagent.
  • Blood from six healthy donors was analyzed, with reagent and calcium volumes adjusted for consistent concentration.

Main Results:

  • No significant disparity between instruments was found for in-tem and RapidTEG reagents.
  • Significant differences were observed for ex-tem and kaolin reagents (α angle, maximum firmness) and the tissue factor reagent (clot time, maximum firmness).
  • Observed differences were small compared to inter-test variations and normal range variations.

Conclusions:

  • TEG and ROTEM instruments demonstrate greater interchangeability for hemostatic assessment than previously reported.
  • Minor parameter differences exist for specific reagents but are generally small.
  • Findings support increased confidence in comparing results between TEG and ROTEM systems.