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The effects of acute cerebrovascular disease on serum and cerebrospinal fluid parameters
Insights
Biochemical markers in cerebrospinal fluid (CSF) can indicate stroke severity. Lactate and pyruvate levels in CSF correlate with stroke severity, while serum markers like CK and LD also show relationships.
Area of Science:
- Neurology
- Biochemistry
- Clinical Chemistry
Background:
- Acute cerebrovascular disease, commonly known as stroke, presents a significant challenge in clinical diagnostics.
- Understanding the biochemical changes in serum and cerebrospinal fluid (CSF) is crucial for assessing stroke severity and impact.
Purpose of the Study:
- To investigate the relationship between acute cerebrovascular disease and various biochemical parameters in serum and CSF.
- To determine the correlation of these parameters with the severity of the stroke.
Main Methods:
- Analysis of biochemical data from 312 patients diagnosed with acute cerebrovascular disease.
- Evaluation of serum and CSF levels of enzymes (CK, LD, ASAT), proteins, albumin, lactate, pyruvate, 5HIAA, and IgG.
Main Results:
- Serum CK, LD, and alpha 1 protein fraction moderately correlated with stroke severity.
- CSF enzymatic activities and CSF/serum albumin ratio did not correlate with stroke severity.
- CSF lactate and pyruvate levels were elevated and showed a clear relation to stroke severity.
- CSF 5HIAA levels were significantly higher in completed stroke compared to Transient Ischemic Attack (TIA).
Conclusions:
- Specific CSF metabolites, lactate and pyruvate, serve as reliable indicators of acute cerebrovascular disease severity.
- Serum markers provide some indication of stroke severity, but CSF analysis offers more specific insights into central nervous system metabolic changes.
- Further research into CSF biomarkers like 5HIAA could aid in differentiating stroke types.
Abstract:
In order to evaluate the effects due to acute cerebrovascular disease on serum and cerebrospinal fluid (CSF) parameters, biochemical data from 312 patients were studied. In serum, CK, LD and alpha 1 protein fraction showed a moderately close relationship to the severity of stroke. In CSF there could not be observed any relation between enzymatic activities (LD, ASAT, CK) and the severity of the disease. The same result was found for CSF protein and the ratio CSF albumin/serum albumin, parameters which are indicative for Blood Brain Barrier (BBB) disturbances. Substances from the intermediate metabolism in the Central Nervous System (CNS) (lactate and pyruvate) were evidently raised in CSF and there was a clear relation between the CSF concentration and the severity of stroke. No indication for IgG immunoglobulin abnormalities in CSF was found. The concentration of neurotransmitter metabolite 5HIAA in CSF was significantly higher in (in)completed stroke than in Transient Ischaemic Attack.