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Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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No appreciable decrease in fertility in Behçet's syndrome.

Didem Uzunaslan1, Caner Saygin, Gulen Hatemi

  • 1Cerrahpasa Tip Fakultesi, Ic Hastaliklari Anabilim Dali, Romatoloji Bilim Dali, Fatih, Istanbul 34098, Turkey. gulenhatemi@yahoo.com.

Rheumatology (Oxford, England)
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Infertility is not significantly increased in Behçet

Keywords:
Behçet’s syndromeco-morbidityfamilial Mediterranean feverinfertility

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Area of Science:

  • Rheumatology
  • Reproductive Medicine
  • Immunology

Background:

  • Behçet's syndrome (BS) impacts childbearing years.
  • Fertility concerns in BS require investigation.

Purpose of the Study:

  • To assess infertility rates in Behçet's syndrome.
  • To evaluate the impact of organ involvement and medications on fertility in BS patients.

Main Methods:

  • Compared fertility in BS patients (with/without organ involvement) to healthy controls and patients with Familial Mediterranean Fever (FMF) and Ankylosing Spondylitis (AS).
  • Utilized structured interviews and reviewed medical records for organ involvement and drug history.

Main Results:

  • No significant increase in infertility was observed in BS patients (male or female) compared to controls.
  • Conception rates, pregnancy outcomes (miscarriages, terminations, ectopic pregnancies) were similar across groups.
  • Infertility was more frequent in BS patients with major organ involvement using cyclophosphamide (CYC).

Conclusions:

  • Behçet's syndrome does not significantly increase infertility risk in patients attending specialized clinics.
  • Major organ involvement did not elevate infertility risk.
  • Cyclophosphamide (CYC) is the only identified drug impacting fertility in BS.