Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

12.3K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
12.3K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

13.4K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crosstalk between and developmental dynamics of Caenorhabditis elegans Argonaute proteins.

Genetics·2026
Same author

Tdrd6a and Tdrd6b are required together for germ plasm formation.

Development (Cambridge, England)·2026
Same author

SLBP-independent control of maternal histone mRNA.

bioRxiv : the preprint server for biology·2026
Same author

SOS: RNA-processing mechanism rescues genes from invasive DNA.

Nature·2025
Same author

Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition.

Biophysical journal·2025
Same author

Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells.

eLife·2025

Related Experiment Video

Updated: May 4, 2026

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
04:59

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster

Published on: March 28, 2025

1.2K

Is this mine? small RNAs help to decide.

Bruno F M de Albuquerque1, René F Ketting2

  • 1Institute for Molecular Biology, Ackermannweg 4, D-55128 Mainz, Germany; Graduate Program in Areas of Basic and Applied Biology, University of Porto, 4099-003 Porto, Portugal.

Developmental Cell
|December 28, 2013
PubMed
Summary

Small RNAs are known to silence foreign DNA. New research reveals these small RNAs can also activate the expression of a cell's own DNA, ensuring essential genes are transcribed.

More Related Videos

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

22.0K
Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA
13:16

Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA

Published on: January 22, 2018

23.3K

Related Experiment Videos

Last Updated: May 4, 2026

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
04:59

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster

Published on: March 28, 2025

1.2K
Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

22.0K
Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA
13:16

Assessment of DNA Contamination in RNA Samples Based on Ribosomal DNA

Published on: January 22, 2018

23.3K

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Genomes face constant threats from foreign DNA.
  • Small RNAs are key regulators of gene expression.
  • The role of small RNAs in silencing foreign DNA is established.

Purpose of the Study:

  • To investigate the role of small RNAs beyond silencing foreign DNA.
  • To determine if small RNAs can also promote the expression of endogenous DNA.
  • To elucidate the mechanisms by which small RNAs regulate trusted DNA.

Main Methods:

  • Analysis of small RNA populations.
  • Gene expression profiling.
  • Computational analysis of genomic data.

Main Results:

  • Small RNAs were found to target and activate specific endogenous DNA sequences.
  • Activation by small RNAs facilitates the expression of essential genes.
  • This mechanism provides a novel layer of gene regulation.

Conclusions:

  • Small RNAs play a dual role in genome defense and regulation.
  • Beyond silencing alien DNA, small RNAs license trusted DNA for expression.
  • This discovery expands our understanding of small RNA function in eukaryotes.