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Related Concept Videos

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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What is Gene Expression?01:36

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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What is Gene Expression?01:42

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
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Updated: May 4, 2026

Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts
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Rounding up natural gene expression variation during development.

Sebastian M Waszak1, Bart Deplancke1

  • 1Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.

Developmental Cell
|December 28, 2013
PubMed
Summary
This summary is machine-generated.

Researchers mapped natural genetic variations influencing gene expression timing during development in the roundworm Caenorhabditis elegans. This study provides a genome-wide view of genetic control over developmental gene dynamics.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Genomics

Background:

  • Understanding the genetic basis of development is crucial.
  • Previous studies primarily relied on single gene mutations.

Purpose of the Study:

  • To create a genome-wide map of natural sequence variants.
  • To investigate how these variants affect gene expression dynamics during development.

Main Methods:

  • Genome-wide analysis of natural sequence variants.
  • Studying gene expression dynamics in Caenorhabditis elegans.

Main Results:

  • A comprehensive map of genetic variants impacting developmental gene expression was generated.
  • The study revealed insights into the temporal dynamics of thousands of genes.

Conclusions:

  • Natural sequence variants play a significant role in regulating developmental gene expression timing.
  • This work provides a foundation for future studies on genetic variation and development.