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[Effect of glutathione on blood coagulation function].
Tong-Qing Chen1, Chang-Chun Chen2, Jun-Xian Wang3
1Department of Blood Transfusion, The Second People Hospital of Anhui Province, Hefei 230011,Anhui Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 28, 2013
Summary
Glutathione (GSH) significantly impacts blood coagulation tests, including prothrombin time (PT) and activated partial thromboplastin time (APTT). This finding is crucial for interpreting coagulation function in clinical settings.
Area of Science:
- Biochemistry
- Hematology
Context:
- Blood coagulation is a complex process vital for hemostasis.
- Glutathione (GSH) is a key endogenous antioxidant with potential roles beyond cellular protection.
- Standard coagulation tests assess the integrity of the coagulation cascade.
Purpose:
- To investigate the influence of varying glutathione (GSH) concentrations on standard blood coagulation parameters.
- To determine the dose-dependent effects of GSH on prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and thrombin time (TT).
Summary:
- Glutathione (GSH) administration significantly altered APTT, FIB, PT, and TT values in plasma samples in a dose-dependent manner.
- Statistically significant differences (P < 0.01) were observed at specific GSH concentrations for each parameter.
- A linear relationship was established between GSH concentrations and the measured coagulation test results.
Impact:
- Findings highlight the potential for GSH to interfere with laboratory assessment of coagulation function.
- Results necessitate consideration of GSH levels when interpreting coagulation test results in patients.
- This research provides a basis for further investigation into GSH's role in hemostasis and thrombosis.
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