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Structural characterization of silicone polymers using compositional ultra-high performance liquid chromatography
Andrew J Hoteling1, Peter T Papagelis1
1Analytical and Material Science Division, Bausch and Lomb, Inc., Rochester, NY 14609, USA.
Analytica Chimica Acta
|December 28, 2013
Summary
A new online ultra-high performance liquid chromatography-high resolution/accurate mass spectrometry method rapidly characterizes silicone polymers. This technique efficiently separates oligomers by molar mass and end-group composition for detailed analysis.
Area of Science:
- Polymer Chemistry
- Analytical Chemistry
- Materials Science
Background:
- Silicone polymers are widely used but complex to characterize.
- Accurate and timely analysis of silicone polymer composition is crucial for quality control and research.
Purpose of the Study:
- To develop an online ultra-high performance liquid chromatography (UHPLC)-high resolution/accurate mass (HR/AM) methodology for rapid silicone polymer characterization.
- To enable detailed analysis of oligomer species based on molar mass and end-group composition.
Main Methods:
- Optimization of electrospray ionization for direct coupling with mass spectrometry.
- Development of reverse-phase UHPLC for high-resolution separation of silicone polymer oligomers.
- Utilizing retention time and accurate mass for identification and data interpretation.
Main Results:
- Successful direct coupling of UHPLC separation with HR/AM spectrometry for silicone polymers.
- High-resolution separation of oligomers by molar mass and end-group composition achieved.
- Rapid identification of multiple pseudo-molecular ion species and oligomer types.
Conclusions:
- The developed UHPLC-HR/AM methodology provides a rapid and information-rich approach for silicone polymer characterization.
- The method is effective for polymer end-group analysis and comparative studies.
- This technique enhances the ability to analyze complex silicone polymer structures efficiently.
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