[Coronary atherosclerosis lesion features in coronary artery disease patients complicating with metabolic syndrome]

Related Experiment Video

Updated: May 4, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K

Yang Gao1, Bin Lü1, Zhi-hui Hou1

  • 1Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing 100037, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|December 28, 2013
PubMed

Insights

Patients with metabolic syndrome (MetS) have more severe coronary artery calcium deposition and calcified plaque in their arteries, leading to worse obstructive coronary artery disease compared to those without MetS.

Area of Science:

  • Cardiology
  • Radiology
  • Metabolic Diseases

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Metabolic syndrome (MetS) is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.
  • Understanding the impact of MetS on coronary atherosclerosis is crucial for risk stratification and management.

Purpose of the Study:

  • To compare coronary plaque burden, composition, and distribution in patients with and without MetS.
  • To assess the degree of coronary artery stenosis in CAD patients with or without MetS.
  • To investigate the relationship between MetS and coronary artery calcium deposition.

Main Methods:

  • Retrospective analysis of 872 patients diagnosed with CAD via invasive coronary angiography (ICA).
  • Coronary computed tomography angiography (CCTA) and ICA were performed within three months.
  • Exclusion of patients with prior percutaneous coronary interventions (PCI) or coronary artery bypass grafting (CABG).

Main Results:

  • MetS patients exhibited significantly higher coronary artery calcium scores (CACS) compared to non-MetS patients.
  • A higher percentage of MetS patients had severe coronary calcium (CACS ≥ 1000) and calcified plaque in middle and distal coronary arteries.
  • MetS patients showed a higher prevalence of multi-vessel disease (2-vessel and 3-vessel disease).

Conclusions:

  • Metabolic syndrome is associated with more severe coronary artery calcification.
  • Patients with MetS have a higher burden of calcified plaque, particularly in the middle and distal coronary arteries.
  • MetS is linked to more severe obstructive coronary artery disease.
Abstract

More Related Videos

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

221
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.6K

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
943
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
620
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
948