Related Experiment Video
Updated: May 4, 2026
07:40
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
5.3K
Uveal effusion associated with an IgM lambda subtype monoclonal gammopathy
1Departamento de Retina y Vítreo, Hospital de l'Esperança, Parc de Salut Mar, Barcelona, España.
Archivos De La Sociedad Espanola De Oftalmologia
|December 28, 2013
Summary
Monoclonal gammopathy of undetermined significance (MGUS) can cause uveal effusion, a rare condition of fluid accumulation in the eye. This case highlights a new association between IgM lambda MGUS and uveal effusion.
Area of Science:
- Ophthalmology
- Hematology
Background:
- Uveal effusion is a rare condition characterized by the accumulation of protein-rich fluid in the suprachoroidal space.
- It can lead to decreased visual acuity and other visual disturbances.
- The exact etiology of uveal effusion remains unclear in many cases.
Observation:
- A 68-year-old male presented with progressive vision loss in his right eye.
- Ophthalmic examination revealed a moderate cataract and annular choroidal thickening.
- Diagnostic imaging, including ultrasound and angiography, confirmed uveal effusion.
Findings:
- Laboratory investigations identified an IgM lambda subtype monoclonal gammopathy of undetermined significance (MGUS).
- This specific subtype of MGUS has not been previously associated with uveal effusion.
- The patient underwent cataract surgery and received a sub-Tenon's triamcinolone injection, resulting in a satisfactory short-term outcome.
Implications:
- This case report suggests a potential link between IgM lambda MGUS and the development of uveal effusion.
- It expands the spectrum of systemic conditions associated with uveal effusion.
- Further research is warranted to elucidate the underlying mechanisms connecting MGUS and uveal effusion.
Related Concept Videos
01:25Pleural Effusion I: Introduction
6.3K
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
6.3K
01:15Transcytosis of IgG
3.4K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.4K