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Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
Published on: May 10, 2024
Wheezing in children with sickle cell disease
Jeffrey A Glassberg1, Robert Strunk, Michael R DeBaun
1aEmergency Medicine, Hematology and Medical Oncology, Mount Sinai School of Medicine, New York bWashington University School of Medicine in St Louis, St Louis, Missouri cVanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Monroe Carell Jr Children's Hospital, Vanderbilt, Nashville, Tennessee, USA.
Wheezing is common in sickle cell disease (SCD) and may indicate intrinsic lung disease. Aggressive treatment of wheezing in SCD is crucial for reducing morbidity and mortality risks.
Area of Science:
- Pulmonology
- Hematology
- Pediatrics
Background:
- Wheezing is a frequent symptom in individuals with sickle cell disease (SCD).
- It can be an indicator of SCD-related lung disease, distinct from asthma.
- Recurrent wheezing in SCD is linked to increased morbidity and mortality.
Purpose of the Study:
- To review the epidemiology, pathophysiology, and clinical management of wheezing in SCD.
- To explore the association between wheezing and SCD-related complications.
- To outline an approach for evaluating and managing wheezing in SCD patients.
Main Methods:
- Comprehensive literature review.
- Analysis of current evidence on wheezing in SCD.
- Synthesis of clinical guidelines for SCD and asthma management.
Main Results:
- Wheezing in SCD can be an intrinsic aspect of SCD-related lung disease.
- Individuals with SCD experiencing recurrent wheezing face higher risks of adverse outcomes.
- Acute management involves beta agonists and short-term oral steroids; asthma guidelines apply for atopic individuals.
Conclusions:
- Wheezing in SCD requires prompt and aggressive management, including controller medications.
- Further SCD-specific clinical trials are needed to evaluate anti-inflammatory asthma therapies for mitigating wheezing sequelae.
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