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Updated: Feb 14, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections
Steve P Bernier1, Matthew L Workentine1, Michael G Surette1
1Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Abstract:
To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.
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