Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.7K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

3.4K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.4K
Cognitive Dissonance01:38

Cognitive Dissonance

29.1K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
29.1K
Groupthink01:34

Groupthink

37.0K
When in group settings, we are often influenced by the thoughts, feelings, and behaviors around us. Groupthink is another phenomenon of conformity where modification of the opinions of members in a group aligns with what they believe is the group consensus (Janis, 1972). In such situations, the group often takes action that individuals would not perform outside the group setting because groups make more extreme decisions than individuals do. Moreover, groupthink can hinder opposing trains of...
37.0K
Social Exchange Theory02:06

Social Exchange Theory

26.3K
We have discussed why we form relationships, what attracts us to others, and different types of love. But what determines whether we are satisfied with and stay in a relationship? One theory that provides an explanation is social exchange theory. According to social exchange theory, we act as naïve economists in keeping a tally of the ratio of costs and benefits of forming and maintaining a relationship with others (Rusbult & Van Lange, 2003).
26.3K
Social Exchange Theory01:26

Social Exchange Theory

896
As formulated by John Thibaut and Harold Kelley, Social Exchange Theory explains human relationships as economic-like exchanges that maximize rewards and minimize costs. This theory suggests that individuals engage in relationships to gain benefits and reduce burdens, similar to economic transactions. It has been widely applied to various types of relationships, including romantic, professional, and social interactions.Rewards and Costs in RelationshipsRelationship rewards include emotional...
896

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical-grade cryopreservation unlocks transplant-ready human pancreatic and stem cell-derived islets for diabetes therapy.

bioRxiv : the preprint server for biology·2026
Same author

In vivo toxicity assessment of silica-coated iron oxide nanoparticles for nanowarming in organ cryopreservation.

Journal of nanobiotechnology·2026
Same author

Conference Report-The Past, Current, and Future Challenges in Transplantation: A Festschrift in Honor of Professor Paul Anthony Keown.

Canadian journal of kidney health and disease·2026
Same author

Prednisone Avoidance After Abdominal Solid Organ Transplantation: A Narrative Review.

Transplantation·2026
Same author

Case Report: Bezoar in allograft duodenum-rare cause of bowel obstruction 13 years post-pancreas transplant.

Frontiers in transplantation·2026
Same author

A Mycophenolate Pharmacokinetic Study with New Insights into Enterohepatic Recirculation in Kidney Transplant Recipients.

Clinical pharmacokinetics·2026

Related Experiment Video

Updated: May 4, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.3K

Tolerance--is it worth it?

Erik B Finger1, Terry B Strom, Arthur J Matas

  • 1Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455.

Cold Spring Harbor Perspectives in Medicine
|December 28, 2013
PubMed
Summary
This summary is machine-generated.

New strategies for immunologic tolerance are emerging in clinical trials, aiming to prevent transplant rejection and reduce the need for immunosuppressants. Evaluating their success is crucial to determine if these tolerance protocols are truly beneficial.

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

13.8K
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.3K

Related Experiment Videos

Last Updated: May 4, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.3K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

13.8K
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.3K

Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Immunosuppressive medications carry risks like cancer, infection, and organ toxicity.
  • Preventing immune rejection after transplantation is a major clinical challenge.

Purpose of the Study:

  • To explore novel cellular and molecular strategies for inducing immunologic tolerance in transplantation.
  • To evaluate the potential of these strategies to improve graft and patient survival by obviating the need for immunosuppression.

Main Methods:

  • Review of emerging cellular and molecular tolerance strategies.
  • Analysis of data from nonhuman transplant models and early-phase clinical trials.

Main Results:

  • Several tolerance strategies show promise in preclinical models.
  • These approaches are now advancing into human clinical trials.

Conclusions:

  • The success of tolerance induction in transplantation requires careful evaluation of associated risks and benefits.
  • Ongoing assessment of clinical trial outcomes is essential to determine the overall value of tolerance protocols.