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Updated: May 4, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Role of Notch signalling pathway in cancer and its association with DNA methylation

Madhuri G S Aithal1, Narayanappa Rajeswari

  • 1Department of Biotechnology, Dayananda Sagar College of Engineering, Bangalore 560 078, India. nraja7@gmail.com.

Journal of Genetics
|December 28, 2013
PubMed

Insights

Notch signalling pathway dysregulation drives cancer by affecting cell fate and survival. Promoter methylation of Notch genes acts as a cancer biomarker and potential therapeutic target.

Area of Science:

  • Cellular biology
  • Molecular oncology
  • Epigenetics

Background:

  • The Notch signalling pathway is crucial for cell fate determination and organism development.
  • Dysregulation of Notch signalling is implicated in various cancers, promoting oncogenesis and cell survival.
  • Epigenetic alterations, particularly DNA methylation, are key drivers of cancer development.

Purpose of the Study:

  • To review the methylation status of Notch signalling pathway genes across diverse cancers.
  • To explore the potential of Notch gene methylation as a biomarker for cancer diagnosis and risk stratification.
  • To highlight the therapeutic implications of targeting epigenetic modifications in Notch-driven cancers.

Main Methods:

  • Literature review focusing on methylation patterns in Notch pathway genes.
  • Analysis of studies linking epigenetic alterations to cancer development and progression.
  • Examination of the role of DNA methylation in Notch signalling and cancer biology.

Main Results:

  • Promoter region methylation is a significant epigenetic alteration in Notch signalling pathway genes in various cancers.
  • Aberrant methylation patterns correlate with cancer development and can serve as diagnostic and prognostic biomarkers.
  • Targeting DNA methylation offers a promising therapeutic strategy for Notch-related malignancies.

Conclusions:

  • Methylation status of Notch signalling pathway genes is a critical epigenetic factor in cancer.
  • Notch gene methylation serves as a valuable biomarker for early cancer detection and patient stratification.
  • Reversing aberrant DNA methylation presents a viable therapeutic avenue for cancers involving the Notch pathway.

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