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Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused

Akishi Okabe1, Yasuomi Urano1, Sayoko Itoh1

  • 1Systems Life Sciences, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.

Redox Biology
|December 28, 2013
PubMed

Keywords:
24S-hydroxycholesterol24SOHC, 24S-hydroxycholesterol7-ketocholesterol7KC, 7-ketocholesterol9cRA, 9-cis retinoic acidABCA1, ATP-binding cassette transporter A1ABCG1, ATP-binding cassette transporter G1AD, Alzheimer's diseaseATP-binding cassette transporter G1Adaptive responsesCYP46A1, cholesterol 24-hydroxylaseCell deathFITC, fluorescein isothiocyanateHDL, high-density lipoproteinLDH, lactate dehydrogenaseLXR, liver X receptorLiver X receptorMAP2, microtubule-associated protein 2MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideNC, negative controlPI, propidium iodideRXR, retinoid X receptoratRA, all-trans retinoic acid

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