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Phrygian Cap Appearance of a Mouse Gallbladder on Magnetic Resonance Imaging

Jean-Pierre Raufman1, Su Xu2, Kunrong Cheng1

  • 1Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Journal of Veterinary Science & Medical Diagnosis
|December 28, 2013
PubMed

Insights

Researchers observed a rare Phrygian cap gallbladder in a healthy mouse using live-animal magnetic resonance imaging (MRI). This finding, previously undocumented in mice, offers new insights into gallbladder anatomy and development.

Area of Science:

  • Veterinary Medicine
  • Radiology
  • Developmental Biology

Background:

  • The gallbladder's anatomy can exhibit variations, with the Phrygian cap being a common congenital anomaly in humans.
  • Murine models are crucial for understanding human diseases and biological processes.

Purpose of the Study:

  • To report the first observed case of a Phrygian cap gallbladder in a mouse.
  • To document this anatomical variation using advanced imaging techniques.

Main Methods:

  • Live-animal magnetic resonance imaging (MRI) was performed on healthy, fasted, and anesthetized male mice.
  • A gas mixture of oxygen and isoflurane was used for anesthesia during small animal MRI.

Main Results:

  • A Phrygian cap appearance of the gallbladder was observed in one 6-week-old male mouse during MRI.
  • Post-euthanasia examination revealed a morphologically normal gallbladder, with no apparent anatomical abnormalities.

Conclusions:

  • This study presents the first documented instance of a Phrygian cap gallbladder in a murine model.
  • The findings suggest potential similarities in gallbladder development or anatomical variations between mice and humans.
Keywords:
GallbladderMousePhrygian capSmall animal MRI

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