Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

33
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
33
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

702
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
702
Healing II: Complications01:24

Healing II: Complications

37
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
37
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

41
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
41
Phases of Wound Repair01:28

Phases of Wound Repair

8.0K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
8.0K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

764
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
764

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranodal Hemangioma as a Differential Diagnosis of Melanoma Metastasis: A Case Report of a Rare Entity.

Acta dermatovenerologica Croatica : ADC·2026
Same author

Predictive Value of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) in Staging of Patients with High-Risk Melanoma.

Acta dermatovenerologica Croatica : ADC·2026
Same author

Long-Term Remission in Stage IIIb Melanoma After Surgical Resection Alone: An Uncommon Clinical Scenario.

Acta dermatovenerologica Croatica : ADC·2026
Same author

Dissecting Cellulitis of the Scalp: Linking Pathogenesis to Therapy.

Biomedicines·2026
Same author

From Immunobiology to Clinical Application: Tumor-Infiltrating Lymphocytes in Melanoma.

Journal of personalized medicine·2026
Same author

Pregnancy-associated melanoma: A distinct entity requiring vigilance.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026

Related Experiment Video

Updated: May 4, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

20.8K

[Chronic wounds: differential diagnosis].

Mirna Situm1, Maja Kolić1

  • 1Klinicki bolnicki centar Sestre milosrdnice, Klinika za kozne i spolne bolesti, Zagreb, Hrvatska.

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|December 31, 2013
PubMed
Summary

Chronic wounds fail to heal within six weeks and are classified as typical or atypical. Atypical chronic wounds, though rare, can signal underlying systemic diseases and require careful diagnosis.

Area of Science:

  • Dermatology
  • Wound Healing
  • Internal Medicine

Background:

  • Wounds disrupt skin continuity, classified as acute or chronic based on healing time (over six weeks).
  • Chronic wounds are categorized into typical (ischemic, neurotrophic, hypostatic) and atypical types.
  • Typical chronic wounds include diabetic foot and decubitus ulcers, with venous insufficiency being the most common cause in lower legs.

Purpose of the Study:

  • To differentiate between typical and atypical chronic wounds.
  • To highlight the diverse etiologies of atypical chronic wounds.
  • To emphasize the diagnostic importance of considering systemic diseases in atypical wound presentations.

Main Methods:

  • Classification of wounds based on healing progression.

More Related Videos

A Simplified Technique for Producing an Ischemic Wound Model
12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

17.0K

Related Experiment Videos

Last Updated: May 4, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

20.8K
A Simplified Technique for Producing an Ischemic Wound Model
12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

17.0K
  • Etiological analysis of chronic wounds, focusing on lower leg presentations.
  • Review of atypical chronic wound causes, including systemic and autoimmune disorders.

    • Main Results:

    • Chronic wounds are defined by delayed healing, typically exceeding six weeks.
    • Lower leg chronic wounds are predominantly caused by chronic venous insufficiency (80%), arterial etiology (5-10%), or neuropathic factors.
    • Atypical chronic wounds stem from a wide range of conditions, such as autoimmune disorders, infections, neoplasms, and drug reactions.

    Conclusions:

    • Atypical chronic wounds, while less common, are crucial indicators of underlying systemic diseases.
    • Systemic conditions like Crohn's disease or immune responses (pyoderma gangrenosum) can manifest as atypical wounds.
    • Thorough diagnostic evaluation is essential to identify systemic origins of atypical chronic wounds.