Optical image-guided cancer therapy
Lihong Bu, Xiaowei Ma, Yingfeng Tu
1Department of Radiology, Molecular Imaging Program at Stanford (MIPS), 1201 Welch Road, Lucas Expansion, P095, Stanford University, Stanford, CA 94305-5484, USA. zcheng@stanford.edu.
Abstract:
Optical molecular imaging holds great promise for image guiding cancer therapy. The non-invasive guidance of therapeutic strategies would enable the removal of cancerous tissue while avoiding side effects and systemic toxicity, preventing damage of healthy tissues and decreasing the risk of postoperative problems. This review article highlights the advantages and disadvantages of the optical imaging techniques that are currently available, including their recent applications in image-guided cancer therapy. Three approaches for optical image-guided cancer therapy were discussed in this review, namely, bioluminescence imaging (BLI), fluorescence imaging (FI) and Cerenkov luminescence imaging (CLI). BLI is always used in small animal imaging for the in vivo tracking of therapeutic gene expression and cell-based therapy. To the contrary, FI display high promising for clinical translation. The applications of FI include image-guided surgery, radiotherapy, gene therapy, drug delivery and sentinel lymph node fluorescence mapping. CLI is a novel radioactive optical hybrid imaging strategy and its use for animal and clinical translation was also discussed. Perspectives on the translation of optical image-guided cancer therapy into clinical practice were provided.
Insights
Optical molecular imaging offers non-invasive guidance for cancer therapy, minimizing side effects. This review covers bioluminescence imaging (BLI), fluorescence imaging (FI), and Cerenkov luminescence imaging (CLI) for improved cancer treatment.
Area of Science:
- Oncology
- Medical Imaging
- Biotechnology
Background:
- Optical molecular imaging is crucial for image-guided cancer therapy.
- Non-invasive guidance minimizes damage to healthy tissues and reduces postoperative complications.
Purpose of the Study:
- To review current optical imaging techniques for cancer therapy.
- To discuss advantages, disadvantages, and applications of bioluminescence imaging (BLI), fluorescence imaging (FI), and Cerenkov luminescence imaging (CLI).
Main Methods:
- Review of existing literature on optical imaging techniques.
- Analysis of applications in image-guided cancer therapy, including surgery, radiotherapy, and drug delivery.
- Discussion of clinical translation potential for BLI, FI, and CLI.
Main Results:
- BLI is primarily used for small animal studies tracking gene expression and cell therapy.
- FI shows significant promise for clinical translation in various applications like image-guided surgery and sentinel lymph node mapping.
- CLI is a novel hybrid imaging strategy with discussed potential for both animal and clinical use.
Conclusions:
- Optical imaging techniques, particularly FI, are advancing image-guided cancer therapy.
- Further development and clinical translation of BLI, FI, and CLI are essential for improved patient outcomes.
- Non-invasive optical guidance enhances precision in cancer treatment, reducing toxicity and improving efficacy.
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