Related Experiment Videos
Antifungal drug resistance mechanisms in pathogenic fungi: from bench to bedside
1National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Abstract:
The phenotypic methods for identification of antifungal resistance are reliable procedures, and MIC determination by reference techniques is the gold standard to detect resistant clinical isolates. In recent years, progress has been made towards the description of resistance mechanisms at molecular level. There are methods of detection that can be useful for clinical laboratories, but lack of standardization precludes their full and effective integration in the routine daily practice. The molecular detection of Candida resistance to azoles and to echinocandins and of Aspergillus resistance to triazoles can be clinically relevant and could help to design more efficient prevention and control strategies. This text reviews the present state of the detection of mechanisms of resistance at the molecular level in Candida spp. and Aspergillus spp. and its relevance to clinical practice.
Related Concept Videos
06:58Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
08:45Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:46Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
07:58Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
06:52Characterizing Herbivore Resistance Mechanisms: Spittlebugs on Brachiaria spp. as an Example
The Roles of Bacteria and Fungi in Plant Nutrition