Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous lignans--a potential endogenous digitalis.

P Braquet, N Senn, J P Robin

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rizzoli's Osteoklast; Hegar's Operation for Fibroid of the Uterus; Akystopeurastic.

    The Chicago medical journal and examiner·2023
    Same author

    A Case of Hydrophobia, with a Brief General Review of the Disease.

    The Chicago medical journal and examiner·2023
    Same author

    Spontaneous Osteo-myelitis of the Long Bones.

    The Chicago medical journal and examiner·2023
    Same author

    Exsection of Hip-Joint for Morbus Coxarius.

    Medical examiner (Chicago, Ill.)·2023
    Same author

    Areolar Carcinoma of Omentum, Simulating Ovarian Tumor.

    Medical examiner (Chicago, Ill.)·2023
    Same author

    An Essay on the Pathology and Treatment of Cancer.

    Medical examiner (Chicago, Ill.)·2023
    Same journal

    Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats.

    Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
    Same journal

    Hypertension and kidney alterations in rat offspring from low protein pregnancies.

    Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
    Same journal

    Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.

    Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
    Same journal

    The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance.

    Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
    Same journal

    Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind.

    Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
    Same journal

    Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects.

    Journal of hypertension. Supplement : official journal of the International Society of Hypertension·2009
    See all related articles

    Mammalian lignans, found in bodily fluids, can inhibit the Na+K+-pump in human red blood cells. This suggests a potential physiological role for these natural products.

    Area of Science:

    • Biochemistry
    • Physiology
    • Pharmacology

    Background:

    • Lignans are natural phenols formed by oxidative dimerization.
    • Mammalian lignans have been detected in human and animal bodily fluids.
    • The physiological role of lignans remains largely unassessed.

    Purpose of the Study:

    • To investigate the effect of mammalian lignans on the Na+K+-pump in human red blood cells.
    • To determine if lignans modulate Na+K+-pump activity.

    Main Methods:

    • Mammalian lignans were obtained via total synthesis or extracted from pregnant women's urine.
    • The inhibitory effects of lignans on Na+K+-pump activity were measured.
    • Half-maximal inhibitory concentrations (IC50) were determined for lignans and ouabain.

    Related Experiment Videos

    Main Results:

    • Enterolactone, prestegane B, and 3-O-methylenterolactone inhibited Na+K+-pump activity.
    • The IC50 values for these lignans ranged from 5 to 9 X 10(-4) mol/l.
    • Lignan addition did not alter the IC50 for ouabain, indicating non-competitive inhibition.

    Conclusions:

    • Certain mammalian lignans exhibit inhibitory effects on the Na+K+-pump in human red blood cells.
    • The non-competitive inhibition suggests lignans interact with the pump at a site distinct from ouabain binding.
    • These findings suggest a potential physiological role for lignans in regulating ion transport.