Related Experiment Video
Updated: May 4, 2026

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects
Published on: October 2, 2014
Unusual presentation of postdural puncture headache requiring repeat epidural blood patch in a 4-year-old child
Bruno C R Borges1, Gail Wong, Lisa Isaac
1Department of Anesthesia, McMaster Children's Hospital/McMaster University, Hamilton, Canada.
Insights
A 4-year-old child needed two epidural blood patches (EBPs) for a postdural puncture headache (PDPH) after a spinal drain. A second EBP, with a larger blood volume, successfully resolved the headache symptoms.
Area of Science:
- Pediatric Anesthesiology
- Neurosurgery
- Neurology
Background:
- Postdural puncture headache (PDPH) can occur after procedures involving the dura mater, such as lumbar cerebrospinal fluid (CSF) drainage.
- Delayed onset PDPH presents a diagnostic and therapeutic challenge, particularly in pediatric patients.
- Epidural blood patching (EBP) is a common treatment for PDPH, but optimal volume and efficacy in children are not well-established.
Observation:
- A 4-year-old child developed delayed onset PDPH following the removal of a lumbar CSF drain.
- The initial epidural blood patch (EBP) using 0.41 ml·kg(-1) of blood was ineffective in alleviating the headache.
- A second EBP, administered two days later with a larger volume of 0.76 ml·kg(-1) of blood, resulted in complete symptom resolution.
Findings:
- The volume of blood required for effective epidural blood patching in pediatric patients with symptomatic CSF leaks may be higher than initially administered.
- A single epidural blood patch may not always be sufficient to treat postdural puncture headache in children.
- Repeat epidural blood patching with an increased volume can be successful in resolving persistent PDPH.
Implications:
- This case highlights the potential need for larger blood volumes in repeat epidural blood patches for pediatric PDPH.
- The findings suggest that current guidelines for EBP volume in children may require re-evaluation.
- Further research is warranted to determine the optimal volume of blood for effective EBP in pediatric patients experiencing CSF leaks and PDPH.
Abstract:
We present the case of a 4-year-old child who required two epidural blood patches (EBPs) to treat a delayed onset postdural puncture headache (PDPH) caused by lumbar cerebrospinal fluid drain. The first EBP was unsuccessful with 0.41 ml·kg(-1) of blood injected. A second EBP with 0.76 ml·kg(-1) of blood was performed 2 days later with the complete resolution of symptoms. The volume of blood necessary for effective treatment for symptomatic cerebrospinal fluid leaks in children remains controversial, and a repeat EBP may be required for resolution of symptoms.
More Related Videos
09:16Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
Published on: June 21, 2019
09:14Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Related Concept Videos
Increased Intracranial Pressure l: Introduction
Brain Abscess l: Introduction
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Increased Intracranial Pressure ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...