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Topical NSAID formulations.

Mary Lynn McPherson1, Nina M Cimino

  • 1School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.

Pain Medicine (Malden, Mass.)
|December 31, 2013
PubMed
Summary
This summary is machine-generated.

Topical nonsteroidal anti-inflammatory drugs (NSAIDs) offer effective pain relief for conditions like osteoarthritis, with a potentially better safety profile than oral NSAIDs. These formulations are increasingly recommended in treatment guidelines.

Keywords:
Nonsteroidal Anti-Inflammatory DrugOsteoarthritisTopical

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Area of Science:

  • Pharmacology
  • Rheumatology
  • Drug Development

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management.
  • Topical NSAID formulations offer an alternative to oral administration.
  • Understanding the benefits and drawbacks of available topical NSAIDs is crucial for clinical practice.

Purpose of the Study:

  • To review currently available topical NSAID formulations in the United States.
  • To analyze the advantages, disadvantages, and therapeutic applications of these products.
  • To discuss adverse effects and formulation considerations for topical NSAIDs.

Main Methods:

  • Literature review of topical NSAID products approved in the U.S.
  • Analysis of clinical studies on the efficacy and safety of topical NSAIDs.
  • Comparison of topical NSAID formulations with oral NSAID counterparts.

Main Results:

  • Approved topical NSAIDs include diclofenac sodium gel, diclofenac sodium topical solution, and diclofenac epolamine patch.
  • Topical diclofenac preparations demonstrate efficacy comparable to oral NSAIDs for osteoarthritis pain.
  • Topical NSAIDs are associated with lower serum concentrations, suggesting a potentially improved safety profile despite shared boxed warnings.

Conclusions:

  • Topical NSAIDs provide significant therapeutic benefits.
  • These agents offer an advantageous adverse effect profile compared to oral NSAIDs.
  • Topical NSAIDs are increasingly incorporated into clinical treatment guidelines.