Histometric analysis of skin-radiofrequency interaction using a fractionated microneedle delivery system
Zhenlong Zheng1, Boncheol Goo, Do-Young Kim
1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea; Department of Dermatology, Yanbian University Hospital, Yanji, China.
Background:
Fractionated microneedle radiofrequency (RF) devices have been reported to be effective in treatment of various dermatologic disorders.
Objectives:
To analyze histometric changes in skin-RF interactions using a fractionated microneedle delivery system.
Materials And Methods:
RF energies were delivered using a fractionated microneedle device to an in vivo minipig model with penetration depths of 0.5, 1.0, 1.5, 2.0, 2.5, and 3.5 mm; RF conduction times of 20, 50, 100, and 1,000 ms; and energy levels of 5.0, 10.0, 20.0, 25.0, 37.5, and 50.0 V.
Results:
Immediately after treatment, skin samples showed that the RF-induced coagulated columns in the dermis formed a cocoon-shaped zone of sublative thermal injury. Four days after the treatment, skin specimens demonstrated reepithelialization, and the dermal RF-induced coagulated columns showed mixed cellular infiltration, neovascularization, and granulation tissue formation. Microneedle depth and RF conduction times, but not energy level, significantly affected histometric values of RF-induced dermal coagulation. Microneedle RF treatment affected adnexal structures by coagulating follicular epithelium and perifollicular structures.
Conclusions:
Our data may be of use as an essential reference for choosing RF parameters in treatment of various skin conditions.
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